Microscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of techniques together with numerous practical applications of importance in drug development. The first section presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification. Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists. Consequently, eachsection has exercises designed to teach the reader how to use and apply the techniques in the book. Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises.

The first edition of this book was written in 1961 when I was Morris Loeb Lecturer in Physics at Harvard. In the preface I wrote: "The problem faced by a beginner today is enormous. If he attempts to read a current article, he often finds that the first paragraph refers to an earlier paper on which the whole article is based, and with which the author naturally assumes familiarity. That reference in turn is based on another, so the hapless student finds himself in a seemingly endless retreat. I have felt that graduate students or others beginning research in magnetic resonance needed a book which really went into the details of calculations, yet was aimed at the beginner rather than the expert. " The original goal was to treat only those topics that are essential to an understanding of the literature. Thus the goal was to be selective rather than comprehensive. With the passage of time, important new concepts were becoming so all-pervasive that I felt the need to add them. That led to the second edition, which Dr. Lotsch, Physics Editor of Springer-Verlag, encouraged me to write and which helped launch the Springer Series in Solid-State Sciences. Now, ten years later, that book (and its 1980 revised printing) is no longer available. Meanwhile, workers in magnetic resonance have continued to develop startling new insights.

The appreciable evolution of the nearly teenaged branch of atomic and molecular physics called beam foil spectroscopy is clearly depicted in the present volumes, which are devoted to publication of presentations at the Fourth International Conference on Beam Foil Spectroscopy and Heavy Ion Atomic Physics Symposium. The transition from childhood to adolescence parallels human experience in that diffusion of interests and interactions beyond the confines of the original family has most certainly occurred. The pre-occupation with techniques and their develop­ ment has been largely replaced by interest in the physics of the widest possible array of atomic and molecular physics experiments, in which spectroscopic study (visible, UV, XUV, X-ray, electron) of collisional interactions of fast beams is the unifying theme. The description "accelerator-based atomic physics" is perhaps more representative of the subject today than is the original, beam-foil spectroscopy," since so many experiments have nothing to do with foils, and furthermore, employ spectroscopy mainly as an incidental tool. What, then distinguishes beam-foil spectro­ scopy from overlapping fields of atomic collisions physics?

The book covers in particular state-of-the-art scientific research about product quality control and related health and environmental safety topics, including human, animal and plant safety assurance issues. These conference proceedings provide contemporary information on the general theoretical, metrological and practical issues of the production and application of reference materials.

This book describes and discusses the applications of electrophoresis in various research fields, including single-cell technology, veterinary diagnosis, dental research, biodiversity study, and soil research.

This book provides a comprehensive overview of Nuclear Magnetic Resonance (NMR) theory, its applications, and advanced techniques to improve the quality and speed of NMR data acquisition. In this book, the author expands his outstanding Ph.D. thesis and provides a valuable resource for researchers, professionals, and students in the field of NMR spectroscopy.

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered.

This book reviews the recent research achievements of the investigation of interfacial phenomena in polymer/polymer and polymer/metal joint interfaces with the state-of-the-art analytical techniques not previously used in the field of adhesion and bonding. Adhesion performance is determined not only by the two-dimensional interfaces but also by a three-dimensional (3D) region having different properties and structural characteristics that extends into the bulk materials. In this book, the authors also discuss in detail the bonding mechanism by characterizing such 3D regions called “interphase”. The book is of great interest to researchers and engineers devoted to adhesion science and technology.

This detailed volume presents a variety of specialized analytical methods on a wide range of glycolipids. From sphingoglycolipids to lipid A, an immune system stimulant present in lipopolysaccharide, the book delves into how glycolipid structure on the surface of the cell membrane, which characterizes each organism, is crucial for the coexistence or repulsion between organisms. In addition, glycolipids play an important role in infections in animals and other organisms by targeting host cell membranes, if enveloped viruses are considered as living organisms. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.

Spectrochemical analysis is a powerful instrumental principle for the determination of the chemical elements and their species in a variety of sample types of different size, at widely di€erent concentration levels and with very di€ering cost performance ratios and time consumption. In addition, not only monoelement but also multielement determinations are possible with widely di€ering precision and accuracy using the various di€erent methods.

A practical guide to ICP emission spectrometry, updated with information on the latest developments and applications
The revised and updated third edition of ICP Emission Spectrometry contains all the essential information needed for successful ICP OES analyses. In addition, the third edition reflects the most recent developments and applications in the field. Filled with illustrative examples and written in a user-friendly style, the book contains material on the instrumentation instructions on how to develop effective methods.

The Second Edition of Practical Gamma-Ray Spectrometry has been completely revised and updated, providing comprehensive coverage of the whole gamma-ray detection and spectrum analysis processes. Drawn on many years of teaching experience to produce this uniquely practical volume, issues discussed include the origin of gamma-rays and the issue of quality assurance in gamma-ray spectrometry. This new edition also covers the analysis of decommissioned nuclear plants, computer modelling systems for calibration, uncertainty measurements in QA, and many more topics.

Nicola Salvi's thesis offers a remarkably cogent view of highly sophisticated NMR methods. Salvi developed these methods in order to characterize the amplitudes and frequency ranges of local motions in biomolecules such as proteins. These local motions play an essential role since they can explain many of the remarkable properties of proteins and enable them to carry out all sorts of vital functions, from enzymatic catalysis to intermolecular recognition and signalling in cells. Salvi's work has led to numerous publications in high-impact journals.

A text- and exercise book for physical chemistry students! This book deals with the fundamental aspects of physical chemistry taught at the undergraduate level in chemistry and the engineering sciences in a compact and practice-oriented form. Numerous problems and detailed solutions offer the possibility of an in-depth reflection of topics like chemical thermodynamics and kinetics, atomic structure and spectroscopy.