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Drugs from Nature: Targets, Assay Systems and Leads

Posted By: AvaxGenius
Drugs from Nature: Targets, Assay Systems and Leads

Drugs from Nature: Targets, Assay Systems and Leads by Madhathilkovilakathu Haridas, Sabu Abdulhameed, Dileep Francis, Swaroop S Kumar
English | PDF EPUB (True) | 2024 | 572 Pages | ISBN : 981999182X | 56.3 MB

This book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery.

Ricin and Shiga Toxins: Pathogenesis, Immunity, Vaccines and Therapeutics

Posted By: AvaxGenius
Ricin and Shiga Toxins: Pathogenesis, Immunity, Vaccines and Therapeutics

Ricin and Shiga Toxins: Pathogenesis, Immunity, Vaccines and Therapeutics by Nicholas Mantis
English | PDF | 2012 | 282 Pages | ISBN : 3642274692 | 4.2 MB

In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventatives or therapeutics for ricin toxin. Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat. It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale.

Tachykinins

Posted By: AvaxGenius
Tachykinins

Tachykinins by Peter Holzer (Professor)
English | PDF | 2004 | 573 Pages | ISBN : 3540206906 | 65.6 MB

More than 70 years have elapsed since U. S. von Euler and I. H. Gaddum dis­ covered an unidentified depressor substance in the brain and gut. The effects of the powdery extracts were marked as 'P' on the kymograph tracings, and the nondescript name of 'substance P' still carries the breath of this adventurous period. In the 1960s, substance P returned in another disguise, staging as a hypothalamic peptide that causes copious salivary secretion (see chapter by F. Lembeck and I. Donnerer). This time, though, the mysterious substance was tracked down by S. E. Leeman and her collaborators as an undecapeptide, after it had eluded its identification for some 40 years.

Environmental Toxicology: Non-bacterial Toxins, 2nd Edition

Posted By: hill0
Environmental Toxicology: Non-bacterial Toxins, 2nd Edition

Environmental Toxicology: Non-bacterial Toxins
English | 2024 | ISBN: 3111014312 | 565 Pages | EPUB (True) | 11 MB

Toxicology of Nanomaterials

Posted By: hill0
Toxicology of Nanomaterials

Toxicology of Nanomaterials
English | 2016 | ISBN: 3527337970 | 628 Pages | EPUB (True) | 15 MB

Computational Physiology: Simula Summer School 2023 − Student Reports

Posted By: AvaxGenius
Computational Physiology: Simula Summer School 2023 − Student Reports

Computational Physiology: Simula Summer School 2023 − Student Reports by Kimberly J. McCabe
English | PDF (True) | 2024 | 120 Pages | ISBN : 3031531442 | 8.9 MB

This volume compiles student reports from the 2023 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions.

Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities

Posted By: AvaxGenius
Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities

Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities by Awanish Mishra, Hitesh Kulhari
English | PDF EPUB (True) | 2024 | 457 Pages | ISBN : 9819968062 | 30.6 MB

This book comprehensively reviews the recent progress in their pathogenesis and management approaches for neurological disorders. It focuses on understanding the molecular mechanism, pathology, novel nanotechnology-based approaches against stroke, Alzheimer’s disease, Parkinson disease, Huntington’s disease, Multiple sclerosis, and Epilepsy. The book provides the basic understanding about the development and progression of these diseases, and recent pharmacotherapeutic approaches for their management. It also discusses challenges in drug development for neurological disorders, including preclinical models of disorders, the need for drugs to cross the blood-brain-barrier, and limited understanding of relevant pathophysiology. The book also focuses on different conventional and novel strategies for drug delivery in neurological disorders. Towards the end, the book reviews the applications of nanotechnology for the diagnosis of neurological disorders. One of the chapters is focused on the role of herbal actives in the treatment of neurological disorders. Finally, a chapter is included on nanotechnology-based approaches for diagnosis of neurological disorders. This book is a useful resource for students and researchers of pharmaceutical sciences, life sciences, material sciences, and nanosciences.

Development of Innovative Drugs via Modeling with MATLAB: A Practical Guide (Repost)

Posted By: AvaxGenius
Development of Innovative Drugs via Modeling with MATLAB: A Practical Guide (Repost)

Development of Innovative Drugs via Modeling with MATLAB: A Practical Guide by Ronald Gieschke , Daniel Serafin
English | PDF (True) | 2014 | 407 Pages | ISBN : 3642397646 | 29.7 MB

The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?

Evaluations

Posted By: AvaxGenius
Evaluations

Evaluations by Gaston Vettorazzi
English | PDF | 1980 | 168 Pages | ISBN : 9401172730 | 19 MB

One of the striking features of our times is the increasing utilization of chemical products in different fields of human activities, as a result of the spectacular progress of chemical research. Our food supply has not been spared from this general trend, however, and chemical sub­ stances are being continuously incorporated in foodstuffs. Some of these substances are added to food for technological purposes such as pre­ serving food from bacterial deterioration (antimicrobials), protecting it from oxidative changes (antioxidants), and improving its organoleptic characteristics (sweeteners, flavors, and flavor enhancers), or texture (stabilizers, emulsifiers, colorants). These substances are generally referred to as intentional food additives.

Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness

Posted By: First1
Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness

Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness by Neil Nathan
English | October 9th, 2018 | ISBN: 1628603119 | 336 pages | True EPUB | 6.50 MB

Millions of people are suffering from chronic illnesses that, unbeknownst to them, are the result of exposure to environmental toxins and infectious agents such as mold and Borrelia, which causes Lyme disease. Millions. Because the symptoms of these illnesses are so varied and unusual, many of these individuals have sought medical care only to be dismissed, as if what they are experiencing is “in their head.” Many (if not most) have tried to tough it out and continue to function without hope of improvement. Unfortunately, their illnesses are very real.

Pharmacology in Noninvasive Ventilation

Posted By: AvaxGenius
Pharmacology in Noninvasive Ventilation

Pharmacology in Noninvasive Ventilation by Antonio M. Esquinas, Bushra Mina, Savino Spadaro, Daniela Perrotta, Francesco De Sanctis
English | PDF (True) | 2024 | 456 Pages | ISBN : 3031446259 | 13.1 MB

This book presents the best practice, indications and drugs most used in the practice of noninvasive ventilation (NIV). In the last two decades NIV has made a lot of progress in different scenarios and etiologies of respiratory failure. The treatment of these patients frequently involves the use of drugs to control patient's symptoms such as dyspnea, discomfort and some of them can have direct or indirect effects on lung function. The volume is organized into various sections - dedicated both to adults as well as pediatrics - where the most frequent clinical conditions requiring for the use of a pharmacological support are described. Furthermore, this book is conceived as a quick reference guide including an analysis of the indications of drugs dosage and the pharmacological interactions that can be observed in lung function in patients undergoing NIV.

Introduction to Toxicology, 4th Edition

Posted By: yoyoloit
Introduction to Toxicology, 4th Edition

Introduction to Toxicology; Fourth Edition
by John Timbrell

English | 2023 | ISBN: 1032036923 | 317 pages | True PDF | 24.53 MB

Most Delicious Poison: The Story of Nature's Toxins - From Spices to Vices

Posted By: readerXXI
Most Delicious Poison: The Story of Nature's Toxins - From Spices to Vices

Most Delicious Poison: The Story of Nature's Toxins - From Spices to Vices
by Noah Whiteman
English | 2023 | ISBN: 031638657X | 132 Pages | PDF (conv) | 26 MB

Encyclopedia of Toxicology, 4th Edition, 9 volume set

Posted By: hill0
Encyclopedia of Toxicology, 4th Edition, 9 volume set

Encyclopedia of Toxicology, 4th Edition, 9 volume set
English | 2024 | ISBN: 0128243155 | 9418 Pages | PDF (True) | 376 MB

Lead Toxicity Mitigation: Sustainable Nexus Approaches

Posted By: readerXXI
Lead Toxicity Mitigation: Sustainable Nexus Approaches

Lead Toxicity Mitigation: Sustainable Nexus Approaches
by Nitish Kumar and Amrit Kumar Jha
English | 2024 | ISBN: 3031461452 | 337 Pages | True PDF | 8 MB