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Lentiviral Vectors and Gene Therapy

Posted By: AvaxGenius
Lentiviral Vectors and Gene Therapy

Lentiviral Vectors and Gene Therapy by David Escors , Karine Breckpot , Frederick Arce , Grazyna Kochan , Holly Stephenson
English | PDF (True) | 2012 | 110 Pages | ISBN : 3034804016 | 1.9 MB

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children.

Molecular Basis of Developmental and Stem Cell Regulation: Classical Models Revised

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Molecular Basis of Developmental and Stem Cell Regulation: Classical Models Revised

Molecular Basis of Developmental and Stem Cell Regulation: Classical Models Revised by Hisato Kondoh
English | PDF EPUB (True) | 2024 | 260 Pages | ISBN : 3031390261 | 90.3 MB

This book provides a comprehensive overview of the molecular basis of developmental and stem cell regulation. It revisits some of the classical models of developmental biology and puts them in context with the findings of modern stem cell research and developmental biology.

Advanced Techniques in Biological Electron Microscopy III

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Advanced Techniques in Biological Electron Microscopy III

Advanced Techniques in Biological Electron Microscopy III by James K. Koehler
English | PDF | 1986 | 289 Pages | ISBN : 3540164006 | 28.6 MB

This volume is a continuation of two prior books on advanced electron microscope techniques. The purpose of this series has been to provide in­ depth analyses of methods which are considered to be at the leading edge of electron microscopic research procedures with applications in the biological sciences. The mission of the present volume remains that of a source book for the research practitioner or advanced student, especially one already well versed in basic electron optical methods. It is not meant to provide in­ troductory material, nor can this modest volume hope to cover the entire spectrum of advanced technology now available in electron microscopy. In the past decade, computers have found their way into many research laboratories thanks to the enormous increase in computing power and stor­ age available at a modest cost. The ultrastructural area has also benefited from this expansion in a number of ways which will be illustrated in this volume. Half of the contributions discuss technologies that either directly or indirectly make extensive use of computer methods.

Fungi Bioactive Metabolites: Integration of Pharmaceutical Applications

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Fungi Bioactive Metabolites: Integration of Pharmaceutical Applications

Fungi Bioactive Metabolites: Integration of Pharmaceutical Applications by Sunil Kumar Deshmukh, Jacqueline Aparecida Takahashi, Sanjai Saxena
English | PDF EPUB (True) | 2024 | 759 Pages | ISBN : 9819956951 | 72.8 MB

This book presents the exploration and exploitation of various bioactive metabolites obtained from fungi isolated from diverse habitats for pharmaceutical applications. Various fungal sources have been brought under one umbrella ranging from endophytes, marine fungi, endolichenic fungi to fungi existing in the extremophilic conditions like desert and Antarctica and Artic environment. The book tries to cover maximally the range of the pharmaceutical applications wherein these bioactive agents from fungi have been exploited or are in the clinical pipelines and primarily include antibacterial, antifungal, antibiofilm, anticancer, antioxidant, autoimmunological, anti-inflammatory, and anti-thrombotic diseases. The book further emphasizes on the novel strategies to screen or enhance secondary metabolite production. Some other topics includes peptides, nonpeptides drugs, pigments, and enhancement of production of Echinocandin and Kojic acid. The role of bioinformatics in drug discovery and biotransformations have also been discussed.

Cell Engineering: Apoptosis

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Cell Engineering: Apoptosis

Cell Engineering: Apoptosis by Mohamed Al-Rubeai, Martin Fussenegger
English | PDF | 2004 | 338 Pages | ISBN : 1402022166 | 5 MB

The series Cell Engineering is the first and only major reference work on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. This volume on "Apoptosis" is intended to review the state-of-the-art with in-depth assessments of this type of programmed cell death.

Pichia Protocols

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Pichia Protocols

Pichia Protocols by David R. Higgins, James M. Cregg
English | PDF | 1998 | 271 Pages | ISBN : 0896034216 | 2.9 MB

David Higgins and James Cregg compile for the first time an all-inclusive collection of key experimental procedures to manipulate Pichia pastoris for gene expression purposes. The methods-developed by world-class researchers in their own laboratories-contain detailed descriptions of available expression strains, as well as vectors and step-by-step instructions for the construction of expression strains and for their use in the production of foreign proteins from shake-flask or fermentor cultures. General procedures for the purification of foreign proteins are also provided, along with protocols for analyzing foreign protein products for glycosylation and subcellular location. Its detailed instructions will permit any researcher in molecular biology to quickly construct an expression strain that will produce a desired foreign protein, and to use this state-of-the-art molecular and cellular biological system successfully in every area of biological research today.

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

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Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues by Irving M. Shapiro , William J. Landis
English | PDF EPUB (True) | 513 Pages | ISBN : 3031343026 | 153 MB

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.

Bioimage Data Analysis Workflows ‒ Advanced Components and Methods (Repost)

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Bioimage Data Analysis Workflows ‒ Advanced Components and Methods (Repost)

Bioimage Data Analysis Workflows ‒ Advanced Components and Methods by Kota Miura, Nataša Sladoje
English | EPUB (True) | 2022 | 218 Pages | ISBN : 3030763935 | 225.5 MB

This textbook aims at providing detailed explanations on how to design and construct image analysis workflows to successfully conduct bioimage analysis.
Addressing the main challenges in image data analysis, where acquisition by powerful imaging devices results in very large amounts of collected image data, the book discusses techniques relying on batch and GPU programming, as well as on powerful deep learning-based algorithms. In addition, downstream data processing techniques are introduced, such as Python libraries for data organization, plotting, and visualizations.

The Chloroplast: Basics and Applications

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The Chloroplast: Basics and Applications

The Chloroplast: Basics and Applications by Constantin A. Rebeiz, Christoph Benning, Hans J. Bohnert, Henry Daniell, J. Kenneth Hoober, Hartmut K. Lichtenthaler, Archie R. Portis, Baishnab C. Tripathy
English | PDF (True) | 2010 | 453 Pages | ISBN : 9048185300 | 15.3 MB

As the industrial revolution that has been based on by higher photosynthetic efficiencies and more utilization of fossil fuels nears its end [R. A. Ker biomass production per unit area. (2007) Even oil optimists expect energy demand to According to Times Magazine (April 30, 2007 outstrip supply. Science 317: 437], the next indus- issue), one fifth of the US corn crop is presently trial revolution will most likely need development converted into ethanol, which is considered to burn of alternate sources of clean energy.

C4 Photosynthesis and Related CO2 Concentrating Mechanisms

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C4 Photosynthesis and Related CO2 Concentrating Mechanisms

C4 Photosynthesis and Related CO2 Concentrating Mechanisms by Agepati S. Raghavendra, Rowan F. Sage
English | PDF (True) | 2011 | 424 Pages | ISBN : 9048194067 | 15.1 MB

The C4 pathway of photosynthesis was discovered and characterized, more than four decades ago. Interest in C4 pathway has been sustained and has recently been boosted with the discovery of single-cell C4 photosynthesis and the successful introduction of key C4-cycle enzymes in important crops, such as rice. Further, cold-tolerant C4 plants are at the verge of intense exploitation as energy crops. Rapid and multidisciplinary progress in our understanding of C4 plants warrants a comprehensive documentation of the available literature. The book, which is a state-of-the-art overview of several basic and applied aspects of C4 plants, will not only provide a ready source of information but also triggers further research on C4 photosynthesis. Written by internationally acclaimed experts, it provides an authoritative source of progress made in our knowledge of C4 plants, with emphasis on physiology, biochemistry, molecular biology, biogeography, evolution, besides bioengineering C4 rice and biofuels. The book is an advanced level textbook for postgraduate students and a reference book for researchers in the areas of plant biology, cell biology, biotechnology, agronomy, horticulture, ecology and evolution.

The Histone Code and Beyond: New Approaches to Cancer Therapy

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The Histone Code and Beyond: New Approaches to Cancer Therapy

The Histone Code and Beyond: New Approaches to Cancer Therapy by S. L. Berger, O. Nakanishi, B. Haendler
English | PDF (True) | 2006 | 223 Pages | ISBN : 3540278575 | 2.5 MB

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

The Structure and Function of Plastids

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The Structure and Function of Plastids

The Structure and Function of Plastids by Robert R. Wise, J. Kenneth Hoober
English | PDF | 2006 | 591 Pages | ISBN : 1402040601 | 34.5 MB

This volume provides a comprehensive look at the biology of plastids, the multifunctional biosynthetic factories that are unique to plants and algae. Fifty-six international experts have contributed 28 chapters that cover all aspects of this large and diverse family of plant and algal organelles. The book is divided into five sections: (I): Plastid Origin and Development; (II): The Plastid Genome and Its Interaction with the Nuclear Genome; (III): Photosynthetic Metabolism in Plastids; (IV): Non-Photosynthetic Metabolism in Plastids; (V): Plastid Differentiation and Response to Environmental Factors. Each chapter includes an integrated view of plant biology from the standpoint of the plastid.

Discoveries in Photosynthesis

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Discoveries in Photosynthesis

Discoveries in Photosynthesis by Govindjee, J. Thomas Beatty, Howard Gest, John F. Allen
English | PDF (True) | 2005 | 1260 Pages | ISBN : 1402033230 | 34.6 MB

"Life Is Bottled Sunshine" [Wynwood Reade, Martyrdom of Man, 1924]. This inspired phrase is a four-word summary of the significance of photosynthesis for life on earth. The study of photosynthesis has attracted the attention of a legion of biologists, biochemists, chemists and physicists for over 200 years. Discoveries in Photosynthesis presents a sweeping overview of the history of photosynthesis investigations, and detailed accounts of research progress in all aspects of the most complex bioenergetic process in living organisms. Conceived of as a way of summarizing the history of research advances in photosynthesis as of millennium 2000, the book evolved into a majestic and encyclopedic saga involving all of the basic sciences.

Skeletal Muscle Repair and Regeneration

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Skeletal Muscle Repair and Regeneration

Skeletal Muscle Repair and Regeneration by Stefano Schiaffino , Terence Partridge
English | PDF (True) | 2008 | 385 Pages | ISBN : 1402067674 | 44.6 MB

Skeletal muscle is the most abundant tissue of our body. Apart from its essential role in locomotion, it is also the body’s main store of carbohydrate and protein as well as being one of the principal generators of heat. Its proper maintenance and function are, therefore, essential. A severe acute loss of muscle function is potentially lethal and the debilitating effects of chronic decline in mobility are commonplace experience, so repair and maintenance of the tissue must by both rapid and effective. Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. The topics range from correlation of changes in pattern of gene expression with the histological sequence during a regenerative episode to the distinctive insult-specific patterns of structural and functional outcome at the other end of the spectrum. The middle ground – who is doing what in this complex process – constitutes the meat of this sandwich.

Human Chromosomes: Structure, Behavior, and Effects

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Human Chromosomes: Structure, Behavior, and Effects

Human Chromosomes: Structure, Behavior, and Effects by Eeva Therman , Millard Susman
English | PDF | 1993 | 392 Pages | ISBN : 0387978712 | 38.2 MB

This book, like the two previous editions, was written as an introduction to human cytogenetics, but it could also be used as a text for a general cytogenetics course, since chromosome structure and behavior are similar in all eukaryotes. Many examples in this book are from organisms other than humans, reflecting our combined backgrounds of molecular and bacterial genetics, and plant and animal cytogenetics. In the rapidly expanding field of human cytogenetics, certain subjects, for instance clinical and cancer cytogenetics, are now covered in recently published, thousand-page volumes. In this book, such subjects are presented only in outline. The enormous growth of information has also made the choice of topics and of examples to illustrate them even more arbitrary and subjective than in the previous editions. Apart from a few pages here and there, the text has been rewritten. Major parts, especially those on molecular matters, have been added. This book would not exist without the dedicated participation of Mrs. Barbara Susman. She has been involved in the project from the planning stages to the final proofreading. She has done the extensive literature research, designed most of the tables and illustrations, and edited and typed the text. For discussions and suggestions we are indebted to many colleagues. We wish especially to mention Drs. Lassi Alvesalo, Evelyn M. Kuhn, and Renata Laxova, who have critically read selected parts of the book, and Dr. Carter Denniston, who has read the whole text.